In this work the magnetron enhanced plasma polymerization was used to produce bio-hemocompatible surface coatings. Their physical and chemical properties as well as their behavior in biological environment in-vivo and in-vitro were investigated. By the precise detection of the protein adsorption, one could devise the best process parameters. The implantation of a coated sensor dummy proved a highly biocompatible respectively bioinert coating. This type of coating drastically increases the functionality and efficiency of many medical implants and in-vivo sensors.