Peri-implantitis is a chronic disease, characterized by an infection around a dental implant. It can lead to bone loss and ultimately to the loss of the implant. There is no standard-therapy to treat peri-implantitis.

AmbiJet represents a new hope to overcome this infection.

more and more implants


Unhealthy food, sugar-based beverage and the ageing of the population pave the way to increased toothlessness. In today’s society, where aesthetics is so important, this has become more than a just functional problem: it is a social issue.

Full toothlessness affects 12% of the 64-year-olds in Germany, 16% in France, 13% in Italy. This gives an impression of how many teeth need replacement.1

Dental implants have become an indispensable established therapy in dentistry to replace missing teeth. It has left the realms of economical niche and reached a broader clientele.

Dental Implants

Dental implant technologies have improved; their cost has decreased; dentists are getting better at inserting them. Implants have consequently democratized and show a growing insertion rate. About 1.3 million implants were inserted in Germany in 2017 alone.2 Approx. 2.3 million implant-supported crowns were placed in the USA in that year.3 In Europe, more than 7 mio. implants were inserted in 2022.

Today, about 34 million implants in Europe and 15 millions in the USA are giving people back their smile and self-confidence.

In the world’s largest market, the US, more than 36 million Americans do not have any teeth, and 120 million people in the U.S. are missing at least one tooth.

American College of Prosthodontists, 2017

A dental implant is a foreign body in the jawbone. Peri-implantitis is the inflammatory reaction resulting from the uncontrolled growth of bacteria on the implant. The bone degrades, which reduces its mechanical integrity and can lead up to a its loss.


Bacteria are a necessary part of our body. Their amount and effects are kept in balance by our immune system. Dental implants are inserted in the jawbone. The immune system is reduced around the foreign body and a disbalance is inevitable.

The European Federation of Periodontics and its American counterpart have defined peri-implantitis as not curable. This means peri-implantitis is a chronic disease and patients need recurring treatments.
The implant’s microstructure is a magnet for bacteria. There is currently no effective standard therapy to treat the infection and save the implants.

Industry-independent studies showed 100% implant related mucositis in patients.4 Worse: after 9 years, 60% of all dental implants present a severe bone loss.5 As of 2022, there are about 28 mio. dental implants in the EU causing pain and restrictions in daily life and requiring a treatment.

Beyond dentistry

A good oral hygiene improves general health, and consequently the overall quality of life of people with dental implants.

Health is our highest Good

The Global Burden of Disease (GBD) is a one of the largest science projects on Earth. It compiles 100,000+ data inputs about 300+ diseases across 200+ countries from all continents. Funded by the Bill & Melinda Gates Foundation, it tracks causes and risks of health loss. In 2019, ‘oral disorders’ were ranked first in prevalence, third in incidence and tenth as cause of disability. In terms of prevalent cases, oral disorders surpassed headache disorders, hearing loss, back pain and diabetes, and concerned about 50% of all causes.6

According to the European Federation of Periodontology and its American counterpart, periodontitis is associated with major chronic inflammatory diseases, including atherogenic cardiovascular disease, diabetes, arthritis, chronic kidney disease, obesity, and chronic obstructive pulmonary disease.7 Oral infections may also affect systemic diseases, such as bacterial pneumonia, or the outcome of pregnancy.8 Indeed, oral cavity is one of the easiest way for viruses and bacteria to enter the body.9 AmbiJet leads to a significant improvement in overall health and reduces healthcare spending in more areas than dentistry alone, for all cost bearers.


Smile shows people’s heart. A healthy smile is a valuable asset for work, everyday-life and overall health. It plays an enormous role in self-esteem and social integration. 87% of adults in the USA agree that having bad teeth negatively impacts your personal life.10 A German study revealed that 75% of people spending 2,000 to 5,000€ on a dental implant earn less than 5,000€ per month as a household.11


1 Fünfte Deutsche Mundgesundheitsstudie. Institut der Deutschen Zahnärzte imAuftrag von Bundeszahnärztekammer und KassenzahnärztlicherBundesvereinigung. 2014.

2 Straumann, “Markets – Position bolstered, addressable market expanded”, 2017, https://www.straumann.com/group/en/discover/annualreport/2017/management-commentary/markets.html.

3 American College of Prosthodontists (ACP), 2017, https://www.gotoapro.org/facts-figures.

4 Cecchinato D, Parpaiola A, Lindhe J. Mucosal inflammation and incidence of crestal bone loss among implant patients: a 10-year study. Clin Oral Implants Res. 2014 Jul;25(7):791–6.

5 Derks J, Schaller D, Håkansson J, Wennström JL, Tomasi C, Berglundh T. Effectiveness of Implant Therapy Analyzed in a Swedish Population. J Dent Res. 2016 Jan 23;95(1):43–9.

6 Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 and Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019, The Lancet.

7 EFP/AAP workshop on periodontitis and systemic diseases. J Clin Periodontol 2013; 40(S14):20-3.

8 Li X, Kolltveit KM, Tronstad L, Olsen I. “Systemic diseases caused by oral infection”. Clin Microbiol Rev. 2000 and Paneer S et al. “Evaluation of Gynecologists’ Awareness About Oral Health Condition During Pregnancy in Chennai City”. J Pharm Bioallied Sci. 2019.

9 Debelian G J, Olsen I, Tronstad L. “Systemic diseases caused by oral microorganisms”. Endod Dent Traumatol, 1994.

10 https://www.statista.com/statistics/1037931/bad-teeth-negatively-impact-life-us-adults-by-age.

11 Marktcheck 2017, Online-Erhebung: Versichertenbefragung zur Risikoaufklärung bei Zahnimplantaten”. Bericht der Verbraucherzentrale, 2018.